Losartán is a drug indicated mainly in cases of hypertension and heart failure, as it acts by promoting the dilation of blood vessels, facilitating the blood flow and, consequently, decreasing the pressure in the arteries and improving the functioning of the heart , reducing the risk of heart attack or stroke, for example.
Therefore, according to the objective of the treatment, the doctor can indicate the most appropriate dose, as well as the time of treatment, also taking into account the age of the person and the use of other medicines.
Losartán should be used only under medical indication and its use should not be interrupted or replaced without medical advice, so that stopping the treatment of hypertension and heart failure may have immediate risks for health, such as infarction, stroke or renal failure .
Losartán binds to the angiotensin receptor, inhibiting its activity and resulting in the dilation of blood vessels. Therefore, this medicine can be indicated by the cardiologist in the following situations:
- Treatment of high blood pressure (hypertension);
- Treatment of heart failure;
- Reduce the risk of cardiovascular disease, stroke and heart attack in people with high blood pressure and left ventricular hypertrophy;
- Protecting the kidneys and slowing the progress of kidney disease in people with type 2 diabetes and proteinuria.
In some situations, losartán can be associated with other medicines to achieve the goals of treatment and promote a better quality of life for the person.
Can Losartan cause cancer?
An alert was recently issued  due to the presence of high levels of impurities in the composition of losartán, called nitrosamines, which can cause cancer in the long term. In this way, the laboratories that manufacture losartán received a notification to evaluate the presence of high levels of these substances in the losartán tablets.
Without embargo, some drug manufacturers  They claim that the risk that these impurities produce cancer is unknown, and there is not enough data to show that losartán has caused some change in frequency or the nature of secondary effects, such as cancer, congenital diseases or fertility problems.
It is important to remember that the treatment with losartán should not be interrupted without the guidance of a doctor, as it can also have serious effects on health, such as a heart attack or stroke. In this way, the ideal is to attend a review consultation with the treating physician to evaluate the possibility of changing to another medication.
Losartán must be taken orally together with a pot of water, before after a meal. Generally, this medication is taken in the morning, but it can be taken at any time of the day, but it can remain active for 24 hours.
The recommended dose must be indicated by a general practitioner or cardiologist, as it varies according to the problem to be treated, the symptoms, and other medications that are being used and the body’s response to the medication.
The general guidelines indicate:
- high pressure: normally, it is advisable to take 50 mg once a day, with the possibility of increasing the dose up to 100 mg;
- Cardiac insufficiency: the initial dose is normally 12.5 mg, once a day, without embargo, it can be increased up to 50 mg over the course of the weeks following medical advice;
- Reduction of cardiovascular disease risk in people with hypertension and left ventricular hypertrophy: the initial dose is 50 mg, once a day, which can be increased to 100 mg or combined with hydrochlorothiazide, depending on the person’s response to the initial dose;
- Renal protection in people with type 2 diabetes and proteinuria: The initial dose is 50 mg daily, which can be increased to 100 mg, depending on the response to blood pressure compared to the initial dose.
Generally, this medication is taken in the morning, but it can be taken at any time of the day, since it maintains its action for 24 hours.
Some of the most common side effects that can arise during treatment with losartán include: mareos, decrease in blood pressure, hyperkalemia, excessive tiredness and vertigo.
Losartán is contraindicated in people who are allergic to the active substance or to any component present in the formula.
Also, this medication should not be used by women who are embarrassed during the lactation period, as well as by people with problems in the liver and kidneys, which is under treatment with medications that contain aliskiren.
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